Journal
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Volume 289, Issue 6, Pages F1170-F1182Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.00072.2005
Keywords
phosphate; secreted frizzled related protein 4; fibroblast growth factor 23; matrix extracellular phosphoglycoprotein; vitamin D
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Funding
- NIDDK NIH HHS [DK-25409, R01 DK065830, DK-65830, DK-58546] Funding Source: Medline
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Phosphate ions are critical for normal bone mineralization, and phosphate plays a vital role in a number of other biological processes such as signal transduction, nucleotide metabolism, and enzyme regulation. The study of rare disorders associated with renal phosphate wasting has resulted in the discovery of a number of proteins [ fibroblast growth factor 23 (FGF-23), secreted frizzled related protein 4 (sFRP-4), matrix extracellular phosphoglycoprotein, and FGF 7 (FGF-7)] that decrease renal sodium-dependent phosphate transport in vivo and in vitro. The phosphatonins, FGF-23 and sFRP-4, also inhibit the synthesis of 1 alpha,25-dihydroxyvitamin D, leading to decreased intestinal phosphate absorption and further reduction in phosphate retention by the organism. In this review, we discuss the biological properties of these proteins, alterations in their concentrations in various clinical disorders, and their possible physiological role.
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