Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 115, Issue 12, Pages 3363-3369Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI26989
Keywords
-
Categories
Ask authors/readers for more resources
The platelet integrin alpha(IIb)beta(3) is required for platelet aggregation. Like other integrins, alpha(IIb)beta(3) resides on cell surfaces in an equilibrium between inactive and active conformations. Recent experiments suggest that the shift between these conformations involves a global reorganization of the alpha(IIb)beta(3) molecule and disruption of constraints imposed by the heteromeric association of the alpha(IIb) and beta(3) transmembrane and cytoplasmic domains. The biochemical, biophysical, and ultrastructural results that support this conclusion are discussed in this Review.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available