Journal
NEUROIMAGE
Volume 28, Issue 4, Pages 1043-1055Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2005.06.059
Keywords
epilepsy; discrimination; correlation; synchrony; dynamics; multivariate
Funding
- NIMH NIH HHS [K02 MH001493, R01 MH50006, K02MH01493, R01 MH050006] Funding Source: Medline
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We developed a modern numerical approach to the multivariate linear discrimination of Fisher from 1936 based upon singular value decomposition that is sufficiently stable to permit widespread application to spatiotemporal neuronal patterns. We demonstrate this approach on an old problem in neuroscience-whether seizures have distinct dynamical states as they evolve with time. A practical result was the first demonstration that human seizures have distinct initiation and termination dynamics, an important characterization as we seek to better understand how seizures start and stop. Our approach is broadly applicable to a wide variety of neuronal data, from multichannel EEG or MEG, to sequentially acquired optical imaging data or fMRI. (c) 2005 Elsevier Inc. All rights reserved.
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