Journal
VISION RESEARCH
Volume 45, Issue 28, Pages 3512-3519Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2005.08.014
Keywords
scanning-laser ophthalmoscopy; animal models; retinal degenerations; angiography
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Scanning-laser ophthalmoscopy is a technique for confocal imaging of the eye in vivo. The use of lasers of different wavelengths allows to obtain information about specific tissues and layers due to their reflection and transmission characteristics. In addition, fluorescent dyes excitable in the blue and infrared range offer a unique access to the vascular structures associated with each layer. In animal models, a further enhancement in specificity can be obtained by GFP expression under control of tissue-specific promotors. Important fields of application are studies in retinal degenerations and the follow-up of therapeutic intervention. (c) 2005 Elsevier Ltd. All rights reserved.
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