Journal
INFECTION AND IMMUNITY
Volume 73, Issue 12, Pages 8393-8396Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.12.8393-8396.2005
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In highly susceptible BALB/c mice infected with Trypanosoma congolense, the total number of Kupffer cells in the liver remains constant; however, their mean size increases fivefold towards the terminal stage. About 25% of Kupffer cells undergo apoptosis. We suggest that development of an impairment of the macrophage system might be a major mechanism for inefficient elimination of trypanosomes.
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