Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 15, Issue 2, Pages 305-311Publisher
WILEY-BLACKWELL
DOI: 10.1111/ajt.13073
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Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [RO1AI091930]
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Over the past several years, the field of transplantation has witnessed significant progress on several fronts; in particular, achievements have been made in devising novel immunosuppressive strategies. An under-explored area that may hold great potential to improve transplantation outcomes is the design of novel strategies to apply specifically to organs to reduce intra-graft inflammation. A growing body of evidence indicates a key role of intra-graft inflammatory cascade in potently instigating the alloimmune response. Indeed, controlling the activation of innate immunity/inflammatory responses has been shown to be a promising strategy to increase the graft acceptance and survival. In this minireview, we provide an overview of emerging targeted strategies, which can be directly applied to grafts to down-regulate intra-graft inflammation prior to transplantation.
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