Journal
ACTA CARDIOLOGICA
Volume 60, Issue 6, Pages 589-598Publisher
TAYLOR & FRANCIS LTD
DOI: 10.2143/AC.60.6.2004929
Keywords
sickle cell disease (SCD); cardiac function; haemolysis; myocardial infarction; pulmonary hypertension
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Cardiovascular abnormalities are often apparent in sickle cell disease, as in other chronic anaemias. Tissue oxygen extraction and cardiac output are increased, while the activated endothelium along with the sickling process and the vaso-occlusion of the small blood vessels strain further the cardiovascular system. Evidence for a specific myocardial lesion attributable to the sickle cell disease is ambiguous through different studies. This article attempts to review the literature about cardiac disease in sickle cell anaemia.
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