Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 96, Issue 5, Pages 927-937Publisher
WILEY-LISS
DOI: 10.1002/jcb.20605
Keywords
collagen; extracellular matrix deposition; posttranslational modification; tumor suppressors
Categories
Funding
- NCI NIH HHS [R01 CA082742, CA082742] Funding Source: Medline
- NIDCR NIH HHS [DE14066, R01 DE014066, DE11004, R01 DE011004, DE12209] Funding Source: Medline
Ask authors/readers for more resources
Collagens are abundant proteins in higher organ isms, and are formed by a complex biosynthetic pathway involving intracellular and extracellular post-translational modifications. Starting from simple soluble precursors, this interesting pathway produces insoluble functional fibrillar and non-fibrillar elements of the extracellular matrix. The present review highlights recent progress and new insights into biological regulation of extracellular procollagen processing, and some novel functions of byproducts of these extracellular enzymatic transformations. These findings underscore the notion that released pro-peptides and other proteolytic products of extracellular matrix proteins have important biological functions, and that structural proteins are multifunctional. An emerging concept is that a dynamic interplay exists between extracellular products and byproducts with cells that helps to maintain normal cellular phenotypes and tissue integrity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available