Journal
FEMS MICROBIOLOGY LETTERS
Volume 253, Issue 1, Pages 59-66Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2005.09.020
Keywords
EHEC; LEE; clpXP; TTSS; rpoS
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Enterohaemorrhagic Escherichia coli (EHEC) contains a 36-kb pathogenicity island termed the locus of enterocyte effacement (LEE), which encodes a type III secretion system (TTSS) and virulence proteins. In this paper, we show that the O157:H7 Sakai clpPX mutant strongly impaired the secretion of virulence proteins by TTSS and repressed transcription from all the LEE promoters. The rpoS mutation in O157:H7 Sakai enhanced the transcription from all the LEE promoters and the secretion of virulence proteins, and it could partially suppress the defects of the clpPX mutation. These data indicate that the O157:H7 Sakai ClpXP protease is a positive regulator for LEE expression and that this regulation occurs by two pathways: the sigma(s)-dependent and -independent pathways. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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