Journal
TOXICON
Volume 46, Issue 7, Pages 797-805Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2005.08.010
Keywords
scorpion; F(ab ')2 antivenom; pharmacokinetics
Categories
Ask authors/readers for more resources
This paper presents the first study of F(ab')(2) Scorpion antivenom pharmacokinetics in humans. We have studied the pharmacokinetics of an antiscorpion venom preparation (Alacramyn (TM)) in eight human healthy volunteers. The fabotherapic was administered as a 47.5 mg i.v. bolus. Blood samples were drawn at 0, 5, 15, 30, 45, 60, 90, 120, 180 and 360 min after antivenom administration. Subsequently, the volunteers made seven visits to the hospital. Four of them at 24 It intervals, one at day 10, and one at day 21. We measured antivenom plasmatic concentrations using a specific high sensitivity ELISA method for F(ab')(2). The time course of F(ab)(2) in serum of seven subjects was well described by a lineal combination of three exponential components; a four exponential component model was necessary to fit the eighth subject. The most significant antivenom. pharmacokinetic parameters determined were: AUC(infinity) = 596.9 (369.3, 891.2) mg h l(-1); V = 3.1 (2.3, 4.3) 1; V-ss = 15.4 (12.8, 39.9) 1; MRT = 250.0 (218.8, 310.2) h; CL = 96.6 (58.0, 139.2) ml h(-1); t(1/2,tau 1) (also called t(1/2,alpha)) = 0.25 (0. 13, 0.37) h; t(1/2,tau z) (corresponding to the slowest component) = 161.3 (141.0, 212.0) h. (c) 2005 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available