Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 28, Issue 12, Pages 1345-1349Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/BF02977900
Keywords
Desmos chinensis; NFAT transcription factor; phenolic constituents
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Six phenolic constituents, 2-methoxybenzyl benzoate (1), negletein (2), 2',3'-dihydroxy-4',6'-dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data. Of these constituents, compounds 2 (IC50: 3.89 +/- 0.39 mu M) and 3 (IC50: 9.77 +/- 0.26 mu M) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 (IC50: 28.4 +/- 2.62 mu M) exhibited moderate inhibitory activity.
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