Journal
LETTERS IN ORGANIC CHEMISTRY
Volume 2, Issue 8, Pages 755-759Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017805774717535
Keywords
4,4-bis(alkylthio)but-3-en-2-one; thiol equivalent; thio-Michael addition; alpha,beta-unsaturated ketone
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4,4-Bis(ethylthio)but-3-en-2-one 1a and 4,4-bis(benzylthio)but-3-en-2- one 1b have been investigated as non-thiolic and odorless thiol equivalents in thio-Michael addition. Promoted by acetyl chloride in methanol, the cleavage of compounds 1a and 1b commenced and the in-situ generated thiols underwent facile acid-catalyzed conjugate addition to alpha,beta-unsaturated ketones 2 affording the corresponding beta-keto sulfides 3 in good yields.
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