Journal
PHYSIOLOGY
Volume 20, Issue -, Pages 374-381Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00028.2005
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Ecto-ADP-ribose transferases (ecto-ARTs) catalyze the transfer of ADP-ribose from NAD(+) to arginine residues in cell-surface proteins. Since the concentration of extracellular NAD(+) is very low under normal physiological conditions but rises significantly upon tissue injury or membrane stress, it is postulated that the main role of ecto-ARTs is to ADP-ribosylate and regulate the function of certain membrane receptors in response to elevated levels of NAD(+).
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