Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 237, Issue 3, Pages 316-322Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2005.04.018
Keywords
intracellular transport; nerve cell; neurofilaments; motor proteins; dynamical system
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Funding
- NINDS NIH HHS [R01 NS038526, NS038526] Funding Source: Medline
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We develop a dynamical system model for the transport of neurofilaments in axons, inspired by Brown's stop-and-go model for slow axonal transport. We use fast/slow time-scale arguments to lower the number of relevant parameters in our model. Then, we use experimental data of Wang and Brown to estimate all but one parameter. We show that we can choose this last remaining parameter such that the results of our model agree with pulse-labeling experiments from three different nerve cell types, and also agree with stochastic simulation results. (c) 2005 Elsevier Ltd. All rights reserved.
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