4.8 Article

Aerobic oxidative cyclization under Pd(II) catalysis: A regioselective approach to heterocycles

Journal

ORGANIC LETTERS
Volume 7, Issue 25, Pages 5717-5719

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol052529c

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An efficient Yb(OTf)(3)-promoted palladium-catalyzed oxidative cyclization of gamma-heteroalkenyl beta-keto amides has been developed. Under simple aerobic condition, a variety of six-, seven-, and eight-membered-ring N- and O-heterocycles were obtained regioselectively in excellent yield.

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