4.8 Article

Concise synthesis of pochonin A, an HSP90 inhibitor

Journal

ORGANIC LETTERS
Volume 7, Issue 25, Pages 5637-5639

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol052263+

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[GRAPHICS] An expedient synthesis of (-)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.

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