Journal
ORGANIC LETTERS
Volume 7, Issue 25, Pages 5649-5652Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol052275v
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Funding
- NCRR NIH HHS [U54 RR020843] Funding Source: Medline
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[GRAPHICS] A solid phase approach is presented for the synthesis of azapeptide inhibitors and activity based probes (ABPs) for cysteine proteases. This synthetic method allows the incorporation of diverse reactive warheads linked to different peptide recognition elements. Application of this method to the synthesis of a series of caspase probes is described.
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