Journal
DNA REPAIR
Volume 4, Issue 12, Pages 1358-1367Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2005.09.001
Keywords
DNA polymerase lambda; family X; non-homologous DNA end-joining; DNA repair; dRP lyase; enzyme mechanism
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Funding
- Intramural NIH HHS Funding Source: Medline
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DNA polymerase lambda is a member of the X family of polymerases that is implicated in non-homologous end-joining of double-strand breaks in DNA and in base excision repair of DNA damage. To better understand the roles of DNA polymerase lambda in these repair pathways, here we review its structure and biochemical properties, with emphasis on its gap-tilling polymerization activity, its dRP lyase activity and its unusual DNA synthetic (in)fidelity. Published by Elsevier B.V.
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