Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 57, Issue 14, Pages 2010-2032Publisher
ELSEVIER
DOI: 10.1016/j.addr.2005.09.004
Keywords
drug delivery; posterior segment; age-related macular degeneration; retina; active and facilitated transporters
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The posterior segments of the eye are exquisitely protected from the external environment. This poses unique and fairly challenging hurdles for drug delivery. It is somewhat dogmatic that topical ocular delivery is insufficient to achieve therapeutic drug levels in the posterior segments. However, some drugs are currently challenging this dogma. In this review we investigate the constraints and challenges of drug delivery to the posterior segment. Additionally, we outline several potential absorption pathways that may potentially be exploited to deliver drug to the back of the eye. Data on several compounds that achieve therapeutic posterior segment concentrations after topical dosing is presented. Finally, the issues surrounding systemic delivery to the posterior segment are reviewed. (c) 2005 Elsevier B.V.. All rights reserved.
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