Journal
NEUROLOGY
Volume 65, Issue 11, Pages 1834-1836Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000187070.35365.d7
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- NCRR NIH HHS [M01-RR00036, M01-RR-01066, M01-RR07122] Funding Source: Medline
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An open-label dose-escalation trial was performed to assess the safety and tolerability of high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in mitochondrial electron transfer, may improve the mitochondrial dysfunction in ALS. In this study, CoQ10 was safe and well tolerated in 31 subjects treated with doses as high as 3,000 mg/day for 8 months.
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