Journal
BRAIN RESEARCH
Volume 1065, Issue 1-2, Pages 132-137Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2005.10.017
Keywords
cocaine; circadian; melatonin; sensitization
Categories
Funding
- NIDA NIH HHS [DA 11787] Funding Source: Medline
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To test the hypothesis that time of day influences the locomotor effects of cocaine in rats, we measured short- and long-term sensitization to cocaine at five different Zeitgeber times (ZT). Short-term sensitization was expressed equally at all ZTs tested. Longterm sensitization was expressed only at dark onset, suggesting a possible influence of melatonin. Exogenous melatonin given immediately before cocaine challenge slightly enhanced long-term sensitization. Taken together, the present results support a time-of-day influence on locomotor sensitization to cocaine. (C) 2005 Elsevier B.V. All rights reserved.
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