Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 57, Issue 15, Pages 2147-2162Publisher
ELSEVIER
DOI: 10.1016/j.addr.2005.09.012
Keywords
dendrimers; encapsulation; solubility enhancement; PEGylation; electrostatic interaction; conjugation; block copolymers
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The interaction between drugs and dendrimers is reviewed with particular reference to the entrapment of drugs within the dendrimer architecture and the electrostatic and covalent complexation of drugs to the dendrimer surface. The application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability and the use of the complexes as vehicles for the controlled release of drugs and drug targeting is discussed. (c) 2005 Elsevier B.V. All rights reserved.
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