Journal
AMERICAN JOURNAL OF CARDIOLOGY
Volume 96, Issue 12, Pages 1636-1639Publisher
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjcard.2005.07.085
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The effect of moderate and intensive lipid lowering on plaque progression and arterial remodeling at coronary branch points was investigated. Intensive (+ 1 +/- 19.6%), but not moderate (+ 4.1 +/- 15.1%), lipid lowering prevented an increase in plaque area at the branch points. The 2 strategies were associated with increased areas of the lumen (+7.6% to 9.4%) and external elastic membrane (+9.6% to 10.8%). In contrast, there was no significant change in plaque, lumen, and/or external elastic membrane areas at the nonbranch point site. These results suggest that intensive lipid lowering can have a dramatic effect on atheroma-prone regions and that remodeling in response to changes in plaque is a heterogenous process. (C) 2005 Elsevier Inc. All rights reserved.
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