Journal
STEROIDS
Volume 70, Issue 14, Pages 954-959Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2005.07.004
Keywords
sponge; Lamellodysidea herbacea; polyhydroxysterol; antifungal activity
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Chemical investigation of the dichloromethane extract of the Red Sea marine sponge Lamellodysidea herbacea led to the isolation of four novel polyhydroxysteroids: cholesta-8-en-3 beta,5 alpha,6 alpha,25-tetrol (1), cholesta-8(14)-en-3 beta,5 alpha,6 alpha,25-tetrol (2), cholesta-8,24-dien-3 beta,5 alpha,6 alpha-triol (3), and cholesta-8(14),24-dien-30,5 alpha,6 alpha-triol (4). Their structures were identified through 1D and 2D NMR studies. Relative stereochemistries were established by analysis of chemical shifts, coupling constants, and NOESY correlations. Compounds 3-4 showed antifungal activity against Candida tropicalis, with an inhibition diameter of 13 and 11 mm at 10 mu g/disc, respectively. (c) 2005 Elsevier Inc. All rights reserved.
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