Journal
CANCER RESEARCH
Volume 65, Issue 24, Pages 11529-11535Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-05-2718
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Funding
- NCI NIH HHS [CA16672, P30 CA016672-279014, CA90270, P50 CA090270-050001, P50 CA090270, P30 CA016672] Funding Source: Medline
- NIGMS NIH HHS [GM64610, R01 GM064610] Funding Source: Medline
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Angiogenesis, the development of new blood vessels from preexisting vessels, is crucial to tissue growth, repair, and maintenance. This process begins with the formation of endothelial cell sprouts followed by the proliferation and migration of neighboring endothelial cells along the preformed extensions. The initiating event and mechanism of sprouting is not known. We show that the phenotypic expression of negatively charged membrane surface in apoptotic cells initiates the formation of directional endothelial cell sprouts that extend toward the dying cells by a mechanism that involves endothelial cell membrane hyperpolarization and cytoskeleton reorganization but is independent of diffusible molecules.
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