Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 96, Issue 6, Pages 1137-1148Publisher
WILEY
DOI: 10.1002/jcb.20615
Keywords
chromatin; histone acetyltransferase (HAT)/deacetylase (HDAC); histone methyltransferase (HMT); aurora kinase; cancer
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Mutations in the molecular pathways that regulate cell proliferation, differentiation, and cell death all contribute to cancer formation. Enzymes that covalently modify histones affect these pathways by controlling the dynamic remodeling of chromatin structure. This article reviews several connections between histone modifying enzymes and cancer that are likely mediated via both histone and non-histone Substrates. We propose that multiple protein modifications, including phosphorylation, methylation, and acetylation, cross regulate one another to coordinate intermolecular signaling, and that miscues in this regulation can lead to oncogenesis.
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