Targeting platinum anti-tumour drugs: Overview of strategies employed to reduce systemic toxicity

Selective drug delivery is an important approach with great potential for overcoming problems associated with the systemic toxicity of chemotherapy, in particular, platinum-based chemotherapy. Finding successful strategies for the targeting of platinum anticancer drugs has therefore been a subject of extensive research. This review paper gives an overview of some of the different approaches that have recently been used in the development of targeted platinum anticancer drugs. (c) 2005 Elsevier B.V. All rights reserved.