Journal
SCIENCE
Volume 310, Issue 5755, Pages 1809-1813Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1114655
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- NINDS NIH HHS [NS050434, NS40528, NS25983] Funding Source: Medline
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Electrical synapses are common between inhibitory neurons in the mammalian thalamus and neocortex. Synaptic modulation, which allows flexibility of communication between neurons, has been studied extensively at chemical synapses, but modulation of electrical synapses in the mammalian brain has barely been examined. We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus.
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