Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 15, Issue 3, Pages 827-832Publisher
WILEY
DOI: 10.1111/ajt.13023
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Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients. Adoptive T cell immunotherapy using cytomegalovirus-specific T cells from a donor bank is used as salvage therapy in a case of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient.
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