Journal
FEBS LETTERS
Volume 579, Issue 30, Pages 6716-6720Publisher
WILEY
DOI: 10.1016/j.febslet.2005.10.067
Keywords
valproic acid; neuroprotection; heat shock protein; Hsp70; p-Akt; p-B cell lymphoma protein-2; phospho-p44/42 mitogen-activated protein kinase
Funding
- PHS HHS [40370, 043567] Funding Source: Medline
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Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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