4.4 Article

An unexpected inversion of enantioselectivity in the proline catalyzed intramolecular Baylis-Hillman reaction

Journal

TETRAHEDRON LETTERS
Volume 46, Issue 51, Pages 8899-8903

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.10.072

Keywords

Baylis-Hillman; proline; intramolecular; inversion

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A highly enantioselective proline catalyzed intramolecular Baylis-Hillman reaction of hept-2-enedial is reported. Addition of imidazole to the mixture results in art unusual inversion of enantioselectivity. (c) 2005 Elsevier Ltd. All rights reserved.

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