Journal
SYNTHESIS-STUTTGART
Volume -, Issue 20, Pages 3654-3665Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-918493
Keywords
combinatorial chemistry; electrochemistry; furans; heterocycles; solid-phase synthesis
Categories
Ask authors/readers for more resources
Electroorganic synthesis has defied application in Solid-Phase Organic Synthesis (SPOS) so far. Typically more than 99.9% of the substrate molecules immobilized on a polymeric support are buried in the interior of the bead, and therefore are unable to undergo direct contact with a heterogeneous reagent such as an electrode. This intrinsic impediment for an electrochemical reaction can be overcome by the use of a redox mediator which shuttles electrons from the electrode to the polymer bound substrate molecules. This approach of indirect electroorganic synthesis was successfully applied for the 2,5-dialkoxylation of furans on solid phase. The oxidation products can be hydrolyzed and through condensation with hydrazine hydrate substituted pyridazines are produced in 50-65% overall yield.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available