Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 51, Pages 18252-18257Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0504628102
Keywords
fluorescence; whole-body imaging; imaging gene expression; gene transfer; multispectral imaging
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Funding
- NCI NIH HHS [R33 CA 91807, R24 CA092782, R33 CA091807, P50 CA086355, P50 CA 86355, R24 CA 92782] Funding Source: Medline
- NIBIB NIH HHS [R01 EB 000750-1, R01 EB000750] Funding Source: Medline
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Volumetric detection and accurate quantification of fluorescent proteins in entire animals would greatly enhance our ability to monitor biological processes in vivo. Here we present a quantitative tomographic technique for visualization of superficial and deep-seated (> 2-3 mm) fluorescent protein activity in vivo. We demonstrate noninvasive imaging of lung tumor progression in a murine model, as well as imaging of gene delivery using a herpes virus vector. This technology can significantly improve imaging capacity over the current state of the art and should find wide in vivo imaging applications in drug discovery, immunology, and cancer research.
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