Journal
JOURNAL OF MICROENCAPSULATION
Volume 22, Issue 6, Pages 581-592Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02652040500162378
Keywords
solid lipid nanoparticles (SLN); alpha lipoic acid; anti-ageing; cosmetics
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This study describes the development, preparation and characterization of solid lipid nanoparticles (SLN(R)) containing the novel anti-ageing substance alpha-lipoic acid. Lipoic acid is chemically labile, i.e. the degradation products possess an unpleasant odour. Therefore, the active was encapsulated in SLN. A lipid with low melting point ( Softisan (R)601) was selected for preparation of active-loaded SLN after screening the solubility of alpha-lipoic acid in physicochemically different lipids. An entrapment efficiency of 90% (UV analysis) was obtained for all developed formulations using Miranol (R)Ultra C32 as emulsifying agent. Particle size stability was monitored during 3 months storing the samples at 20 degrees C and at 4 degrees C. Results of DSC analysis confirm that these systems are characterized by a solid-like behaviour, although with a very low crystallinity index.
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