Journal
DALTON TRANSACTIONS
Volume -, Issue 24, Pages 3829-3837Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b510778d
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Funding
- NCI NIH HHS [R21 CA084697, R33 CA084697, CA-84697] Funding Source: Medline
- NCRR NIH HHS [RR-02584, P41 RR002584] Funding Source: Medline
- NIBIB NIH HHS [R21 EB004285-01, R21 EB004285-02, EB-04285, R21 EB004285] Funding Source: Medline
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The gadolinium(III) complex of S-SSSS-NO(2)BnDOTMA exhibits water exchange kinetics that are optimal for use in high relaxivity or targeted contrast agents. However, the synthesis of this ligand is hampered by the steric encumbrance imparted upon the cyclen ring by the nitrobenzyl substituent. A relatively simple modification has been used to enable the synthesis of larger quantities of a bifunctional ligand that retains similar fast water exchange properties. The gadolinium complex of S-SSS-NO(2)BnD03MA-1A is shown to retain the rapid water exchange kinetics characteristic of a twisted square antiprismatic (TSAP) coordination geometry (tau(M) = 6 +/- 0.4 ns).
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