Journal
ORGANIC LETTERS
Volume 7, Issue 26, Pages 5829-5832Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol052473m
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We describe the synthesis of new environmentally sensitive fluorescence probes to elucidate DNA structures. DNA oligonucleotides containing fluorophore dan (6-(dimethylamino)-2-acylnaphthalene)-modified dC or dG were able to monitor the microenvironmental changes in both the major and minor grooves of DNA with a B- to A-DNA conformational transition and RNA hybridization.
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