Journal
SCIENCE
Volume 310, Issue 5756, Pages 1957-1960Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1117637
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Funding
- NHLBI NIH HHS [T32 HL007572] Funding Source: Medline
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Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema (dob) mutant that fails fin regeneration during initial steps, forms abnormai regeneration epithelium, and does not form blastema. This mutation has no impact on embryonic survival. Dob results from an fgf20a null mutation, Y148S. Fgf20a is expressed during initiation of fin regeneration at the epithelial-mesenchymal boundary and later overlaps with the blastema marker msxb. Thus, fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation.
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