Journal
SCIENCE
Volume 310, Issue 5756, Pages 1960-1963Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1121925
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The mechanisms that protect mammalian cells against amino acid deprivation are only partially understood. We found that during an acute decrease. in external amino acid supply, before up-regulation of the autophagosomal-lysosomai pathway, efficient translation was ensured by proteasomal protein degradation. Amino acids for the synthesis of new proteins were supplied by the degradation of preexisting proteins, whereas nascent and newly formed polypeptides remained largely protected from proteolysis. Proteasome inhibition during nutrient deprivation caused rapid amino acid depletion and marked impairment of translation. Thus, the proteasome plays a crucial rote in cell survival after acute disruption of amino acid supply.
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