Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1100, Issue 1, Pages 108-115Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2005.09.017
Keywords
HPLC; SFC; enantioselective chromatography; cbz derivatives; chiral amines; pharmaceuticals; preparative separations
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The carbobenzyloxy (cbz) protecting group is evaluated for it's potential to enhance the resolution of chiral amine enantiomers using high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC). A series of cbz derivatives of commercially available racemates was prepared and analyzed by enantioselective chromatography using a variety of mobile phases and polysaccharide and Pirkle-type chiral stationary phases (CSPs). The cbz-derivatized product consistently demonstrated enhanced chiral resolution under HPLC and SFC conditions. Improved selectivity and resolution combined with an automated preparative HPLC or SFC system can lead to the rapid generation of highly purified enantiomers of desirable starting materials, intermediates or final products. (c) 2005 Elsevier B.V. All rights reserved.
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