Journal
SCIENCE
Volume 310, Issue 5756, Pages 1966-1970Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1119407
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Funding
- NIDA NIH HHS [DA00074, DA000266] Funding Source: Medline
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Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.
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