Multicomponent one-pot procedure for the synthesis of free α-chiral amines from aldehydes

The synthesis of free a-chiral amines by a one-pot multicomponent procedure from commercially available starting materials is described. This enantioselective reaction involves a catalytic asymmetric addition of dialkylzinc reagents to N-diphenylphosphinoylimines with use of an air-stable precatalyst complex 1. The a-chiral amines are prepared with a one-pot procedure from alkyl and aryl aldehydes in good yield (41-90%) and with excellent enantioselectivity (90-97% ee).