Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 52, Pages 18785-18792Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0509437102
Keywords
cytoskeleton; development
Categories
Funding
- NIGMS NIH HHS [R37 GM052857, GM62580, P01 GM062580, GM52857, R01 GM026357, GM26357] Funding Source: Medline
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This, our Inaugural Article as Academy Members, is ironically our swan song from the field of the actin cytoskeleton. By reviewing what we have learned and what we think is going on during development, we hope to lure you, the reader, into applying your skills to the bristle cell. The processes of the assembly and disassembly of actin bundles is laid out in time and space in an organism that lends itself to genetic manipulation. The cell provides every process you could want: filament nucleation, growth of microvilli, joining of microvillar bundles into modules, assembly of modules into bundles, time-dependent use of at least two crossbridging proteins, filament turnover, treadmilling, disassembly, and filament translocation.
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