Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1746, Issue 3, Pages 274-283Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2005.06.004
Keywords
Ras; microdomain; lipid raft; acylation; plasma membrane; endomembrane
Categories
Funding
- NIGMS NIH HHS [GM066717, R01 GM066717-03, R01 GM066717] Funding Source: Medline
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Ras proteins are compartmentalized by dynamic interactions with both plasma membrane microdomains and intracellular membranes. The mechanisms underlying Ras compartmentalization involve a series of protein/lipid, lipid/lipid and cytoskeleton interactions, resulting in the generation of discrete microdomains from which Ras operates. Segregation of Ras proteins to these different platforms regulates the formation of Ras signaling complexes and the generation of discrete signal outputs. This temporal and spatial modulation of Ras signal transduction provides a mechanism for the generation of different biological outcomes from different Ras isoforms, as well as flexibility in the signal output from a single activated isoform. (c) 2005 Elsevier B.V. All rights reserved.
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