Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1738, Issue 1-3, Pages 1-5Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2005.11.006
Keywords
human caspase-2; SREBP; lipid; transcriptional regulation; intron
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Sterol Regulatory Element Binding Proteins (SREBP) are transcription factors that regulate lipid synthesis. We have shown recently that the human CASP-2 gene, encoding procaspase-2, was under the positive control of SREBP-2 that transactivates several responsive elements in the promoter region. We describe here the function of an additional SREBP-responsive element located in the first intron. Remarkably, this site is uniquely responsive to SREBP-1c that is mainly involved in fatty acids synthesis. This observation, together with our recent findings, strengthens the notion that the CASP-2 gene belongs to the SREBP-responsive gene battery in human cells. (c) 2005 Elsevier B.V. All rights reserved.
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