Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1746, Issue 3, Pages 314-321Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2005.07.007
Keywords
AB(5) toxin; GM1; lipid raft; retrograde transport; ceramide; ganglioside; sphingomyclin; cholesterol; cholera toxin; Shiga toxin
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Funding
- NIDDK NIH HHS [DK34854, DK48106, DK57827] Funding Source: Medline
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Cholera and the related AB(5)-subunit toxins co-opt plasma membrane (PM) glycolipids to move retrograde into the endoplasmic reticulum (ER) of the host cell where a portion of the toxin is retro-translocated to the cylosol to induce disease. Only glycolipids that associate strongly with detergent insoluble membrane microdomains can sort the toxins backwards from PM to ER. The way certain lipids and proteins are clustered in the plane of the membrane to form lipid rafts likely explains how the glycolipids can function as sorting motifs for the toxins. (c) 2005 Elsevier B.V. All rights reserved.
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