Journal
NEUROSCIENCE LETTERS
Volume 390, Issue 3, Pages 171-175Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.08.020
Keywords
electroconvulsive shock; frontal cortex; phosphorylation; protein kinase; protein phosphatase 2A; rat brain
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We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glycogen synthase kinase-3 beta (GSK-3 beta), and cyclic adenosine monophosphate response element binding protein (CREB) were reduced immediately after ECS treatment. When an additional ECS was administered after the activation of these kinases, the immediate reactivation of PP2A overrode the kinase activity. ECS induces transient PP2A activation prior to kinase activation, and this pattern of activity may induce the biphasic phosphorylation of substrate proteins. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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