Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume 1754, Issue 1-2, Pages 232-238Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2005.07.033
Keywords
PRS (proline-rich sequence); SH3 domain; GYF domain; WW domain; register shift; peptide binding
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Recognition of proline-rich sequences plays an important role for the assembly of multi-protein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that share characteristic features. For many complex systems containing proline-rich sequences, multiple binding modes have been found by theoretical and/or experimental studies. In this review, we discuss the different binding modes as well as the correlated dynamics of the peptides and their recognition domains, and some implications to their biological functions. Further-more, we give an outlook of the systems in the context of systems biology. (c) 2005 Elsevier B.V. All rights reserved.
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