Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 1, Pages 217-222Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3227-05.2006
Keywords
nucleus accumbens; motivation; gating; striatum; appetitive behavior; consummatory behavior
Categories
Funding
- NIDA NIH HHS [R01 DA001949, R37 DA001949, DA01949] Funding Source: Medline
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The nucleus accumbens (NAcc) is critical in the control of goal-directed behavior. Pharmacological studies suggest that the NAcc may act in both instructive and permissive modes; however, previous electrophysiological studies in behaving rats have reported firing patterns consistent with an instructive, but not permissive, role for NAcc neurons. We now report that a subset of NAcc neurons shows a long-lasting inhibition in firing rate whose onset precedes initiation of goal-directed sequences of behavior and terminates at the conclusion of the sequence. Together with data from previous behavioral studies, this firing pattern suggests that, when active, these neurons tonically inhibit appetitive and consummatory behaviors and that, when inhibited, these neurons permissively gate those behaviors.
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