Journal
NEURON
Volume 49, Issue 1, Pages 143-155Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2005.10.037
Keywords
-
Categories
Funding
- Medical Research Council [MC_U138169944] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [MC_U138169944] Funding Source: UKRI
- Medical Research Council [MC_U138169944] Funding Source: researchfish
Ask authors/readers for more resources
We observed sharp wave/ripples (SWR) during exploration within brief (< 2.4 s) interruptions of or during theta oscillations. CA1 network responses of SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility or sleep were similar. However, neuronal activity during eSWR was location dependent, and eSWR-related firing was stronger inside the place field than outside. The eSPW-related firing increase was stronger than the baseline increase inside compared to outside, suggesting a supralinear summation of eSWR and place-selective inputs. Pairs of cells with similar place fields and/or correlated firing during exploration showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential activation of place cells was not required for the reactivation of waking co-firing patterns; cell pairs with symmetrical cross-correlations still showed reactivated waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing during eSWRs facilitates initial associations between cells with similar place fields that enable place-related ensemble patterns to recur during subsequent sleep-SWRs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available