4.7 Article

Expedited palladium-catalyzed amination of aryl nonaflates through the use of microwave-irradiation and soluble organic amine bases

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 1, Pages 430-433

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo052131u

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Funding

  1. NIGMS NIH HHS [GM 5-T32-CAO9112-30, GM 58160, GM 1S10RR13886-01] Funding Source: Medline

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Microwave-assisted, palladium-catalyzed C-N bond-forming reactions with aryl/heteroaryl nonaflates and amines using the soluble amine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) or MTBD (7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene) and ligands (1-3) resulted in good to excellent yields (71-99%) of arylamines in short reaction times (1-45 min).

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